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350 Hudson St. Fourth Floor Office Rental
- 39,016 SQFT
- Lease Term Negotiable
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Occupying an entire floor and delivered in whitebox condition, this full-floor office opportunity is designed to give an incoming tenant maximum flexibility while benefiting from a highly efficient, column-aware footprint and extensive perimeter frontage. Arrival onto the floor brings you into a broad central zone that naturally functions as a reception and informal gathering area, positioned to anchor circulation throughout the space. From this central point, the layout opens outward into expansive open work areas that can be organized into long benching runs or clustered team seating, easily supporting a dense yet orderly workstation environment while preserving clear sightlines and intuitive movement across the floor.
Along the perimeter, a series of enclosed rooms are evenly distributed to take advantage of consistent window lines and natural light exposure. These perimeter rooms are well suited for use as private offices, executive offices, or client-facing meeting rooms, allowing leadership and external visitors to benefit from daylight while keeping core work areas uninterrupted. Multiple conference rooms are positioned along the exterior walls as well, scaled to accommodate both small strategy sessions and larger formal meetings. Additional meeting rooms are located closer to the interior, providing convenient breakout options for team huddles, project reviews, or video conferencing without disrupting surrounding workstations.
The floorplate is organized around a centralized building core that houses elevators, stairs, and support infrastructure, allowing the surrounding space to remain highly efficient and largely unobstructed. Adjacent to the core, areas are naturally suited for pantry buildout, copy and storage zones, IT closets, and wellness or support rooms, enabling a clean separation between operational functions and primary work areas. The symmetry of the layout allows departments to be grouped logically while maintaining equal access to meeting rooms and shared amenities.
Ceiling heights and wide structural bays enhance the sense of openness throughout the floor, while the whitebox condition gives tenants a blank canvas to tailor finishes, lighting, and layout to match branding and workflow needs. With its full-floor presence, abundant perimeter rooms, and balanced mix of open and enclosed spaces, the office supports a wide range of occupiers, from growing technology firms to professional services organizations seeking a scalable, future-proof workplace that can evolve alongside their business.
Notes: Whitebox condition. Full floor opportunity!
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350 Hudson St
About the Building
350 Hudson Street is a large loft-style office building in Manhattan’s Hudson Square neighborhood, occupying the block between King Street and Charlton Street. Originally constructed in 1927 as an industrial building, the property has been comprehensively renovated and converted into modern office space while preserving the high ceilings, substantial floor loads, oversized windows, and open floor plans associated with Hudson Square’s historic printing and warehouse buildings.
The nine-story property contains approximately 324,000 square feet of office and retail space, with exceptionally large floor plates measuring roughly 39,000 square feet. These expansive floors are particularly well suited to companies that want to consolidate employees onto one or two levels rather than divide operations across multiple smaller floors. Office layouts can accommodate dense open work areas, private offices, conference rooms, collaboration areas, lounges, pantries, production space, and other employee amenities.
Renovations to 350 Hudson Street have included new mechanical, electrical, and air-conditioning systems, upgraded passenger and service elevators, renovated common areas, new windows, exterior restoration, and a modernized lobby. The building also retains a loading dock and freight infrastructure inherited from its industrial past, providing additional functionality for larger commercial tenants. Portions of the upper floors have access to outdoor terrace space.
Medidata Solutions is a major tenant at 350 Hudson Street, occupying approximately 177,000 square feet across the building’s upper floors. The property has also attracted companies in technology, design, advertising, consumer products, and other creative industries, including PepsiCo’s Design and Innovation Center.
The building’s location places tenants between SoHo, Tribeca, and the West Village, with restaurants, cafés, hotels, shopping, and neighborhood amenities within a short walk. The Spring Street C and E subway station is nearby, providing convenient transportation to Midtown and other parts of Manhattan.
For businesses searching for office space in Hudson Square, 350 Hudson Street is notable for its approximately 39,000-square-foot floor plates, loft-style architecture, abundant natural light, high ceilings, modern building infrastructure, and location within one of Manhattan’s established technology, media, and creative office districts. It is particularly well suited to mid-size and large companies seeking efficient open-plan office space with the character of a traditional Downtown Manhattan loft building.
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